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Johns Hopkins scientists find new compound that may prevent reperfusion injury

first_img Source: Reviewed by James Ives, M.Psych. (Editor)Feb 21 2019In a strategic search, Johns Hopkins scientists created and screened a library of 45,000 new compounds containing chemical elements of widely used immune system suppressants, and say they found one that may prevent reperfusion injury, a tissue-damaging and common complication of surgery, heart attack and stroke.The Johns Hopkins team dubbed its newly discovered compound rapadocin and has filed patents on it and its family of 45,000 chemical cousins. It also has licensed the drug to Baltimore-based biotechnology company Rapafusyn Pharmaceuticals, which was co-founded by the study’s leader, Jun O. Liu, Ph.D., a professor of pharmacology and oncology at the Johns Hopkins University School of Medicine. The researchers caution that any commercialization or clinical use of the drug must await substantial further safety and benefit studies in people.A report on the method used to create and identify rapadocin, as well as laboratory tests of it in mice with reperfusion injuries in their kidneys appeared Dec. 10 in Nature Chemistry.”Reperfusion injuries are a common complication after surgery, especially in the elderly,” says Liu who oversees a library of thousands of the world’s ever-used medicines banked at the Johns Hopkins Drug Library.The injury occurs when, after surgery, doctors release clamps on blood vessels and a surge of oxygenated blood flows back into tissues that were temporarily starved of it. The wave of blood can shock the tissues causing inflammation and organ damage. The condition can also happen when clogged arteries are opened after heart attacks and strokes. Currently, there are a number of drugs being studied to treat reperfusion injuries, and some treatments, such as blood thinners and anti-inflammatory drugs, can be mildly effective for certain types of the condition.To find the new drug, Liu, who co-directs the Cancer Chemical and Structural Biology Program at the Johns Hopkins Kimmel Cancer Center, recalled his postdoctoral training years studying how a drug called rapamycin works. Essentially, it suppresses the immune system and is often prescribed to kidney transplant patients to prevent rejection of their new organs.”I have always thought that rapamycin had interesting qualities,” says Liu. “It’s very stable and cells can absorb high quantities of it, particularly because of its chemical structure.”Chemically, rapamycin and another immunosuppressant drug, called FK506, contain a unique scaffold that forms nearly half of a ring. That half of the ring, called the FKBP-binding domain, is nearly identical between the two drugs, and the other half, the so-called effector domain, is unique to each of them. The FKBP-binding domain of the drugs confers a number of advantages, including stability and greater distribution throughout the body. The effector domain is what makes each drug target a different protein to suppress the immune system or inhibit cancer cell growth.Related StoriesTen-fold rise in tongue-tie surgery for newborns ‘without any real strong data’Scientists discover new compound that visualizes and kills antibiotic-resistant superbugsCopper compound with potential as therapy for ALS shows further promiseInspired by the unique chemical architectures of rapamycin and FK506, Liu wondered whether it was possible to build similar ring-shaped molecules by swapping out the effector domain of rapamycin and replacing it with new building blocks to target other proteins involved in human diseases.To do so, Liu and his team made 45,000 combinations of compounds with a FKBP-binding domain and different effector domains. “We could have made many more combinations, but only had a certain amount of resources to work with,” recalls Liu.Liu and his team divided the massive pool of 45,000 compounds into 3,000 smaller groups and tested each group for those that blocked a chemical pathway associated with reperfusion injury.That pathway is a pump system called equilibrative nucleoside transporter, or ENT, which transports a molecule called adenosine, an important biological messenger, into the cell. Tissues starved for oxygen produce large quantities of adenosine. Adenosine protects cells from damage by connecting with receptors on the surface of cells. To control how much and how long adenosine connects with its receptor, cells can dampen the activity of adenosine by swallowing it into the cell through the ENT transporter. “So the goal is to keep adenosine outside of the cell longer to treat reperfusion injuries,” says Liu.To keep adenosine outside the cell, the scientists looked for the compounds that blocked ENT activity and kept the most adenosine outside the cells to have its tissue-protective effect for as long as possible. One compound rose to the top of their experiments, and they named it rapadocin.In laboratory studies of 25 mice, the scientists injected them with rapadocin, removed one of their kidneys and clamped the other for 45 minutes; 24 hours later, they sampled their blood for levels of creatinine and nitrogen, which are markers of reperfusion injury.The animals given rapadocin had one-third less creatinine (0.4 milligrams per deciliter compared with 0.6 milligrams per deciliter on average) and less than half of nitrogen levels (40 milligrams per deciliter compared with 90 milligrams per deciliter on average) than control mice that were given a drug to cancel the effects of rapadocin.Currently, rapadocin is being developed by Rapafusyn Pharmaceuticals as a potential treatment for kidney reperfusion injury.last_img read more

Bacterial and fungal toxins found in popular electronic cigarettes

first_img Source: Reviewed by James Ives, M.Psych. (Editor)Apr 24 2019Popular electronic cigarette (e-cigarette) products sold in the U.S. were contaminated with bacterial and fungal toxins, according to new research from Harvard T.H. Chan School of Public Health.The study, which examined 75 popular e-cigarette products–cartridges (single use) and e-liquids (refillable material)–found that 27% contained traces of endotoxin, a microbial agent found on Gram-negative bacteria, and that 81% contained traces of glucan, which is found in the cell walls of most fungi. Exposure to these microbial toxins has been associated with myriad health problems in humans, including asthma, reduced lung function, and inflammation.”Airborne Gram-negative bacterial endotoxin and fungal-derived glucans have been shown to cause acute and chronic respiratory effects in occupational and environmental settings,” said David Christiani, Elkan Blout Professor of Environmental Genetics and senior author of the study. “Finding these toxins in e-cigarette products adds to the growing concerns about the potential for adverse respiratory effects in users.”The study will be published online in Environmental Health Perspectives on April 24, 2019.The use of e-cigarettes has been steadily climbing in recent years, especially among high school and middle school students. It’s estimated that more than three million high school students used e-cigarettes in 2018, up from 220,000 in 2011. Previous research from Harvard Chan School has shown that chemicals linked with severe respiratory disease are found in common e-cigarette flavors. Moreover, research by investigators conducted over many decades has shown chronic lung impairment in populations exposed to airborne biological contaminants. Yet, according to the authors, no research exists on the potential contamination of e-cigarettes with microbes or microbial toxins.Related StoriesBacteria in the birth canal linked to lower risk of ovarian cancerNanoparticles used to deliver CRISPR gene editing tools into the cellResearch sheds light on sun-induced DNA damage and repairFor this study, the researchers selected 37 e-cigarette cartridges, sometimes referred to as “cigalikes,” and 38 e-liquid products, which can be used to refill certain cartridges, from the 10 top-selling U.S. brands. The products were classified into four different flavor categories: tobacco, menthol, fruit, and other. All of the products were then screened for the presence of endotoxin and glucan.The findings showed that 17 of 75 products (23%) contained detectable concentrations of endotoxin and that 61 of 75 products (81%) contained detectable concentrations of glucan. Further analysis showed that cartridge samples had 3.2 times higher concentrations of glucan than the e-liquid samples. Glucan concentrations were also significantly higher in tobacco- and menthol-flavored products than in fruit-flavored products. The study also found that endotoxin concentrations were higher in fruit-flavored products, indicating that raw materials used in the production of flavors might be a source of microbial contamination.The researchers noted that the contamination of the products could have occurred at any point during the production of the ingredients or of the finished e-cigarette product. They hypothesized that cotton wicks used in e-cigarette cartridges may be one potential source of contamination, as both endotoxin and glucan are known contaminants of cotton fibers.”In addition to inhaling harmful chemicals, e-cig users could also be exposed to biological contaminants like endotoxin and glucan,” said Mi-Sun Lee, research fellow and lead author of the paper. “These new findings should be considered when developing regulatory policies for e-cigarettes.”Joseph Allen, assistant professor of exposure assessment science, was also a co-author.last_img read more

Rutgers researchers create new device to see if targeted cancer therapy is

first_imgWe built a portable platform that can predict whether patients will respond positively to targeted cancer therapy. Our technology combines artificial intelligence and sophisticated biosensors that handle tiny amounts of fluids to see if cancer cells are sensitive or resistant to chemotherapy drugs.”Senior author Mehdi Javanmard, an assistant professor in the Department of Electrical and Computer Engineering in the School of Engineering at Rutgers University-New Brunswick Novel technologies like this can really have a positive impact on the standard-of-care and result in cost-savings for both healthcare providers and patients.”Co-author Joseph R. Bertino, resident researcher at Rutgers Cancer Institute of New Jersey, professor at Rutgers Robert Wood Johnson Medical School Reviewed by James Ives, M.Psych. (Editor)Jul 17 2019Rutgers researchers have created a device that can determine whether targeted chemotherapy drugs are working on individual cancer patients.The portable device, which uses artificial intelligence and biosensors, is up to 95.9 percent accurate in counting live cancer cells when they pass through electrodes, according to a study in the journal Microsystems & Nanoengineering. The device provides immediate results and will allow for more personalized interventions for patients as well as better management and detection of the disease. It can rapidly analyze cells without having to stain them, allowing for further molecular analysis and instantaneous results. Current devices rely on staining, limiting the characterization of cells.”We envision using this new device as a point-of-care diagnostic tool for assessing patient response and personalization of therapeutics,” the study says.Treatment of cancer patients often requires drugs that can kill tumor cells, but chemotherapy destroys both tumor cells and healthy cells, causing side effects such as hair loss and gastrointestinal problems.Related StoriesNew protein target for deadly ovarian cancerLiving with advanced breast cancerHow cell-free DNA can be targeted to prevent spread of tumorsCo-author Joseph R. Bertino, a resident researcher at Rutgers Cancer Institute of New Jersey and professor at Rutgers Robert Wood Johnson Medical School, and his team previously developed a therapeutic approach that targets cancer cells, such as those in B-cell lymphoma, multiple myeloma and epithelial carcinomas. It binds a chemotherapy drug to an antibody so only tumor cells are targeted, and minimizes interaction with healthy cells. Patients will respond positively to this therapy if their tumor cells generate a protein called matriptase. Many patients will benefit while the side effects from standard chemotherapy are minimized. The Rutgers team tested their new device using cancer cell samples treated with different concentrations of a targeted anti­cancer drug. The device detects whether a cell is alive based on the shift in its electrical properties as it passes through a tiny fluidic hole. The next step is to perform tests on tumor samples from patients. The researchers hope the device will eventually be used to test cancer therapies on samples of patient tumors before treatment is administered. Source:Rutgers UniversityJournal reference:Ahuja, K. et al. (2019) Toward point-of-care assessment of patient response: a portable tool for rapidly assessing cancer drug efficacy using multifrequency impedance cytometry and supervised machine learning. Nature Microsystems & Nanoengineering. read more

Summertime safety guidelines for children

first_imgReviewed by Alina Shrourou, B.Sc. (Editor)Jun 20 2019Summer weather makes it much easier to motivate your kids to get off the couch and away from their screens. But while summer is a great time for families to spend time enjoying the outdoors, it is also the time of year when kids age 14 and younger are most frequently injured.When you and your kids are enjoying the summer weather -; by biking, hiking, swimming, at the playground, or just in the backyard -; be sure to follow these guidelines to keep your family safe.Wear a helmet!When biking, skating, or riding a scooter, make sure your kids are always wearing a helmet. Helmets can help absorb and cushion blows to the head and reduce the risk of serious head and brain injury by 85 percent.When choosing the right helmet to wear, make sure it is snug (the helmet does not slide side-to-side, forward, or backward), level (the helmet does not tilt, fully covers the top of the forehead, and sits squarely), and stable (the chinstrap fixes the helmet in place and it does not rock back and forth). Get a helmet your kids like, as this will make them much more likely to wear it. Lead by example and wear a helmet yourself.It’s important to always ride on the right side of the road, with traffic, and wear high visibility gear. Avoid riding at night.Heat and sun safetyIf your kids are going to be spending time in the hot summer sun, take proper steps to avoid conditions such as heatstroke, dehydration, and sunburn. Supervise your kids and make sure they get enough to drink -; water is always the best choice -; especially if they are running around in the sun or sweating in the heat.Always apply sunscreen on your kids’ skin before they go outside. The American Academy of Pediatrics (AAP) recommends using SPF 15 or greater and reapplying at least every two hours, or after swimming or sweating.Insect safetyOne of the hazards of the outdoors is insect bites or stings. These can be painful, cause allergic reactions, contain toxins, or even transmit illnesses such as Lyme disease. There are several ways to protect kids against insect bites and stings, including: Water safetyPlaying in the water can be a lot of fun for kids and families, but it is also one of the most dangerous activities for children. Drowning is one of the leading causes of injury deaths in the U.S., and kids -; particularly age five and younger -; can be especially vulnerable. To keep your kids safe around water, follow these guidelines: Use an insect repellent that contains between 10 percent to 30 percent of the active ingredient DEET. Always check that you are using the appropriate amount of insect repellent based on age, and reapply it after swimming according to instructions. Do not use insect repellent with DEET for infants younger than two months old. Avoid wearing flowery clothing, bright colors, and perfumes as these can attract insects. Many experts think that ticks need to be attached for at least 24 to 48 hours to cause tick-related illnesses such as Lyme disease. So check your kids for ticks every night to reduce the risk of getting Lyme disease or other tick-borne illnesses. Neighborhood safetyRelated StoriesNew network for children and youth with special health care needs seeks to improve systems of careAn active brain and body associated with reduced risk of dementiaResearchers identify gene mutations linked to leukemia in children with Down’s syndromeTaking your kids to neighborhood hangouts and local events is a great way for them to meet peers, make friends, and learn how to be a part of the community. It’s important to make sure that these events and locations are safe for your children.Playgrounds. Playgrounds can seem like the most child-friendly places to go -; after all, they are built for kids! But each year in the U.S., more than 200,000 children are treated for playground-related injuries. Most of these injuries are fall-related and occur on swings, monkey bars, or climbing sets.To reduce the risk of your child being injured at a playground, make sure that the ground underneath and around the play area is a soft material such as rubber, mulch, sand, or wood chips. Make sure the playground is clear of tripping hazards, like tree stumps, and has guardrails that are in good condition. Supervise your child, particularly when on swings, monkey bars, or climbing sets.Fireworks. Kids and adults alike love watching fireworks. It can be tempting to go over to your neighbor’s home to watch them set off a display, or even purchase fireworks yourself. However, fireworks -; even “safe” fireworks such as sparklers -; can reach temperatures exceeding 1,800 degrees and cause serious burns.One-quarter of fireworks injuries to kids occur when they are bystanders, and many of the rest occur while they are playing with fireworks under adult supervision. If you and your family are going to enjoy fireworks, the safest way to do so is by attending an event managed by trained professionals. Avoid buying fireworks for home use.Trampolines. Bouncing on a trampoline may be your child’s dream, but trampolines are one of the most common causes of serious, even catastrophic, injury. According to the latest data from the U.S. Consumer Product Safety Commission, in 2014 alone, there were more than 100,000 trampoline-related injuries that had to be treated in an emergency department.The AAP does not recommend trampolines in any setting. However many kids use them anyway. So while I also do not endorse trampoline use, the following information might be useful to lower injury risk. Make sure the trampoline has a net and shock-absorbing pads covering the springs, hooks, and frames. Allow only one person on at a time, do not allow kids under age six to use a full-size trampoline, and prohibit your kids from doing somersaults or flips. Keep kids from going under the trampoline where they could be injured by someone bouncing above them. Always supervise your kids on a trampoline. And if you own a trampoline, verify your insurance covers trampoline-related injury.Enjoy summer!Put down the devices, enjoy the great weather, and spend family time outdoors. Have a safe, healthy, and fun summer! Source:Western Connecticut Health Network If you have any type of water near your house, make sure kids cannot get outside on their own. Keep pools fenced in and make sure doors and gates are self-locking. Do not leave kids near water unsupervised. If your child is five years old or younger, practice “touch supervision” around water, always keeping your child within arms reach. Adult supervisors should have CPR training. Be careful around inflatable pools because kids may lean on the sides and fall in. Avoid stagnant water. Mosquitoes and water-borne diseases thrive in and around stagnant water. Contact your healthcare provider and local health authority if you think you or your child may have contracted a water-borne disease. When boating, the U.S. Coast Guard recommends that kids wear life jackets. In Connecticut, all children 12 and under must wear a life jacket at all times on a boat. Always seek emergency medical attention after a near drowning, especially if your child was submerged for more than five minutes; life support (e.g., CPR, rescue breathing) was administered 10 minutes or more from the time of the event; or resuscitation took more than 25 minutes from the time of the event.last_img read more

New strategies for preventing and coping with rising burden of brain diseases

first_imgReviewed by James Ives, M.Psych. (Editor)Jul 1 2019New strategies for preventing and coping with the growing burden of brain diseases were outlined today at the 5th European Academy of Neurology (EAN) Congress in Oslo, Norway.Professor Anne Hege Aamodt, President of the Norwegian Neurological Association, presented The Norwegian Brain Health Strategy 2018-2024 to attendees at the congress. Norway are the first country in Europe to launch a national brain health strategy, which has four overarching aims: Brain diseases now account for 10% of the global burden of disease. Dementia, one of the most common brain diseases, now affects around 50 million people worldwide with 10 million new cases every year. By 2030, it’s estimated that the number of people living with dementia will reach 82 million and this is expected to increase to 152 million by 2050. 1.Good lifelong brain health, prevention and quality of life 2.The provision of user-centred care, as well as support for relatives 3.The organisation of holistic care from multi-disciplinary teams 4.Ensuring adequate knowledge and quality through research and innovation Brain diseases affect a wide range of people in all stages of life and, as people are living for longer, greater numbers now live with a range of brain diseases. Prevention of brain diseases, the provision of equal treatment, follow-up and rehabilitation, as well as increased research and expertise, is absolutely vital in providing patients with optimal outcomes. This strategy will help to facilitate this for a number of brain diseases, including dementia, multiple sclerosis, Parkinson’s and stroke-related conditions.”Professor Anne Hege Aamodt, President of the Norwegian Neurological Association Initiatives outlined in the plan are now underway, which include the funding of a €20 million National Clinical Research Centre devoted to the clinical treatment of severe diseases such as MS, dementia and amyotrophic lateral sclerosis (ALS). In addition, the Norwegian Research Council will also receive an additional €5 million for strengthening research and innovation in neurological conditions.The Norwegian Neurological Association and the Norwegian Directorate of Health are working to action further objectives outlined in the plan, which is being seen as a model template for other European countries to follow.Professor Aamodt adds, “We believe that this national strategy should be replicated and implemented across Europe, tailored for each country. The continent will undergo major societal transformations, such as the ageing population, that will impact on brain diseases and health services must adapt to these changes.”Related StoriesPosterior parietal cortex plays crucial role in making decisions, research showsNeural pathways explain the relationship between imagination and willingness to helpMercy Medical Center adds O-arm imaging system to improve spinal surgery resultsFollowing the launch of the Norwegian Brain Health Strategy, EAN and European Federation of Neurological Associations (EFNA) are also calling for a European Brain Health Plan raise public awareness of brain diseases, lobby governments and integrate the best science to improve outcomes for both patients and society.Also at EAN 2019: Focusing on the burden of stroke and dementia:Professor Vladimir Hachinski, world-renowned stroke expert, stressed during the EAN Congress that stroke accounts for 42% of neurological disease, compared to 10% for dementia and that many cases of dementia could be prevented by preventing stroke.Professor Hachinski said the quest to find a cure for Alzheimer’s in the past 40 years had focused on the amyloid/tau plaque hypothesis, but although this research had improved understanding of the dementia process, this ‘monorail’ approach had so far failed to yield a single disease-modifying drug.Professor Hachinski stated “The good news is that stroke is 90% potentially preventable through the control of risk factors. Stroke and dementia share the same treatable risk factors and their control is associated with a decrease in stroke and some dementias. Additionally, intensive control of risk factors and enhancement of protective factors improve cognition. Anticoagulation treatment of atrial fibrillation patients decreases their chance of developing dementia by 48 %. Preliminary data suggests that treating blood pressure to a target of 120mmHg systolic, compared to a target of 140mmHg, decreases the chances of mild cognitive impairment by 19%.”Professor Hachinski said neurological disorders are now responsible for the largest number of disability-adjusted life years (DALYs – a combined index of early mortality and years spent in disability). He added that the introduction of a stroke strategy in Ontario, Canada, which included building stroke units, stroke prevention clinics and campaigns to control risk factors, helped decrease the number of strokes by 32% over 12 years, with a 7% reduction in the incidence of dementia.He stressed that whilst advancing age, genetic factors and family history couldn’t be changed, many other risk factors for stroke could be modified with physical activity, antihypertensive drugs, following a Mediterranean diet, an active lifestyle and taking statins to lower cholesterol.Professor Hachinski concluded: “Neurological disorders represent the leading cause of DALYs. More than half result from stroke and dementia, which are both preventable to different degrees. We need new vistas and approaches to grasp the opportunity of preventing stroke and some dementias, beginning now.” Source:Spink Healthlast_img read more

Facebook profit up 20 percent to 426 bn

Citation: Facebook profit up 20 percent to $4.26 bn (2018, January 31) retrieved 18 July 2019 from Revenue in the quarter leapt 47 percent to nearly $13 billion, but expenses also rose as its ranks of employees growing by the same percentage to finish the year at 25,105 workers.Facebook shares fell more than 4 percent to $179 in after-market trades that followed release of the earnings figures. Netflix shares jump as subscriptions top 100 million Explore further © 2018 AFP This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Credit: CC0 Public Domain Facebook on Wednesday reported that its profit in the final three months of last year climbed 20 percent to $4.26 billion as ad revenue and ranks of members grew. read more

Quantum radar will expose stealth aircraft

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Stealth aircraft in the Canadian arctic will be no match for a new quantum radar system. Researchers at the University of Waterloo are developing a new technology that promises to help radar operators cut through heavy background noise and isolate objects—including stealth aircraft and missiles—with unparalleled accuracy.”In the Arctic, space weather such as geomagnetic storms and solar flares interfere with radar operation and make the effective identification of objects more challenging,” said Jonathan Baugh, a faculty member at the Institute for Quantum Computing (IQC) and a professor in the Department of Chemistry who is leading the project with three other researchers at IQC and the Waterloo Institute for Nanotechnology (WIN). “By moving from traditional radar to quantum radar, we hope to not only cut through this noise, but also to identify objects that have been specifically designed to avoid detection.”Stealth aircraft rely on special paint and body design to absorb and deflect radio waves—making them invisible to traditional radar. They also use electronic jamming to swamp detectors with artificial noise. With quantum radar, in theory, these planes will not only be exposed, but also unaware they have been detected.Technology to improve national defenceQuantum radar uses a sensing technique called quantum illumination to detect and receive information about an object. At its core, it leverages the quantum principle of entanglement, where two photons form a connected, or entangled, pair.The method works by sending one of the photons to a distant object, while retaining the other member of the pair. Photons in the return signal are checked for telltale signatures of entanglement, allowing photons from the noisy environmental background to be discarded. This can greatly improve the radar signal-to-noise in certain situations.But in order for quantum radar to work in the field, researchers first need to realize a fast, on-demand source of entangled photons. “The goal for our project is to create a robust source of entangled photons that can be generated at the press of a button,” said Baugh.To date, quantum illumination has only been explored in the laboratory. The Government of Canada, under the Department of National Defence’s All Domain Situational Awareness (ADSA) Science & Technology program, is investing $2.7 million to expedite its use in the field.The 54 North Warning System (NWS) radar stations, based in the Arctic and operated by the North American Aerospace Defense Command (NORAD), are nearing the end of their life spans and could need to be replaced as early as 2025.”This project will allow us to develop the technology to help move quantum radar from the lab to the field,” said Baugh. “It could change the way we think about national security.” Explore further Citation: Quantum radar will expose stealth aircraft (2018, April 23) retrieved 18 July 2019 from New research signals big future for quantum radar Provided by University of Waterloo Credit: University of Waterloo read more

Arizona dam at risk of failure will be checked by engineers

first_img A helicopter flies over floodwaters filling Menagers Lake, where the dam was in imminent danger of failing, potentially sending floodwaters rushing into the Tohono O’odham village of Ali Chuk, but has now held steady as the lake behind it receded Wednesday, Oct. 3, 2018, southwest of Sells, Ariz. Evacuations had begun Tuesday night after Hurricane Rosa’s remnants drenched the western half of Arizona. (Mike Christy/Arizona Daily Star via AP) The earthen Menagers Dam that was in imminent danger of failing, potentially sending floodwaters rushing into this Tohono O’odham village of Ali Chuk, has held steady as the lake behind it receded Wednesday, Oct. 3, 2018, southwest of Sells, Ariz. Evacuations had begun Tuesday night after Hurricane Rosa’s remnants drenched the western half of Arizona. (Mike Christy/Arizona Daily Star via AP) The dam suffered “some erosional damage” when it was overtopped by water as the lake behind it grew in size because of heavy rains that started Tuesday, the National Weather Service said in a statement that extended a flash flood warning until Thursday afternoon for the village of Ali Chuk on the Tohono O’odham Indian Nation reservation.Tribal officials said in a statement late Wednesday that water levels behind the dam were receding but that its structural integrity was still “a major concern” and that the tribe was working to put together an engineering team to inspect the dam.Most of Ali Chuk’s residents have been evacuated or left on their own but tribal officials said Wednesday that a few refused to leave.Elsewhere, part of a northern Arizona highway was closed Thursday because of storm damage after the remnants of Tropical Storm Rosa dumped rain throughout the state.The northbound lanes of U.S. 89 were closed in the small community of Cameron and southbound lanes were closed at a highway junction north of Cameron, the Arizona Department of Transportation said in a statement.Repairs will probably require an extended closure, meaning drivers will have to take alternative routes with much longer travel time, the department said. A damaged earthen dam holding back a lake swollen by runoff from the remnants of a tropical storm was still at risk of failing Thursday and inundating a small Native American village near the U.S.-Mexico border, officials said. The earthen Menagers Dam, top left, that was in danger of failing, potentially sending floodwaters rushing into the Tohono O’odham village of Ali Chuk, top right, held steady as the lake behind it receded Wednesday, Oct. 3, 2018, southwest of Sells, Ariz. Evacuations had begun Tuesday night after Hurricane Rosa’s remnants drenched the western half of Arizona. (Mike Christy/Arizona Daily Star via AP) © 2018 The Associated Press. All rights reserved. The earthen Menagers Dam that was in imminent danger of failing, potentially sending floodwaters rushing into the Tohono O’odham village of Ali Chuk, has held steady as the lake behind it receded on Wednesday, Oct. 3, 2018, southwest of Sells, Ariz. Evacuations had begun Tuesday night after Hurricane Rosa’s remnants drenched the western half of Arizona. (Mike Christy/Arizona Daily Star via AP) Citation: Arizona dam at risk of failure will be checked by engineers (2018, October 4) retrieved 17 July 2019 from A helicopter flies over floodwaters filling Menagers Lake, where the dam was in imminent danger of failing, potentially sending floodwaters rushing into the Tohono O’odham village of Ali Chuk, but has now held steady as the lake behind it receded Wednesday, Oct. 3, 2018, southwest of Sells, Ariz. Evacuations had begun Tuesday night after Hurricane Rosa’s remnants drenched the western half of Arizona. (Mike Christy/Arizona Daily Star via AP) The earthen Menagers Dam is in imminent danger of failing, potentially sending floodwaters rushing into the Tohono O’odham village of Ali Chuk, Ariz. on Wednesday, Oct. 3, 2018, southwest of Sells, Ariz. Evacuations had begun Tuesday night after Hurricane Rosa’s remnants drenched the western half of Arizona. (Mike Christy/Arizona Daily Star via AP) Explore further The earthen Menagers Dam that was in imminent danger of failing, potentially sending floodwaters rushing into the Tohono O’odham village of Ali Chuk, has held steady as the lake behind it receded Wednesday, Oct. 3, 2018, southwest of Sells, Ariz. Evacuations had begun Tuesday night after Hurricane Rosa’s remnants drenched the western half of Arizona. (Mike Christy/Arizona Daily Star via AP) The earthen Menagers Dam, top left, that was in danger of failing, potentially sending floodwaters rushing into the Tohono O’odham village of Ali Chuk, top right, held steady as the lake behind it receded Wednesday, Oct. 3, 2018, southwest of Sells, Ariz. Evacuations had begun Tuesday night after Hurricane Rosa’s remnants drenched the western half of Arizona. (Mike Christy/Arizona Daily Star via AP) Flooding from remnants of tropical storm traps Phoenix cars This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.last_img read more

Solar energy expert shares blueprint for a carbonfree future in PVtech power

first_imgCredit: CC0 Public Domain Though critics argue these targets are not realistic, solar energy expert Richard Perez believes he holds the blueprint to success.Perez, a senior research associate at the University at Albany’s Atmospheric Sciences Research Center (ASRC), has published a new paper in PV-Tech Power that describes his cost-effective solution to bridge the gap between production of renewables—such as solar and wind—and customer demand. It combines the use of oversized renewable assets and energy curtailment.According to Perez, energy storage technologies have long been considered a critical component of achieving high use of renewables. For example, solar photovoltaic (PV) panels can collect energy from the sun during the daytime and use electrochemical battery storage to meet demands after sunset and during winter or other seasonal variations. However, large and longer-timescale solar supply gaps are more complicated and expensive to maintain.Instead, Perez and his co-authors, suggest a “counterintuitive strategy.” By building oversized renewable assets, more energy is produced, limiting seasonal imbalances and the need for a large amount of storage. The oversizing strategy is combined with a practice called curtailment, which reduces output to below capacity during peak times, saving money and resources. Last year, California set the nation’s most ambitious energy goal—deriving 100 percent of its electrical power from renewable sources by 2045. Many other states have since joined with similar goals, including New York, with Gov. Cuomo’s “Green New Deal” calling for 100 percent carbon-free electricity by 2040. Perez’s 3-minute YouTube explainer on his scalable strategy to 100 percent renewables, which he refers to as the “Perfect Forecast.” “There are many promises for 100 percent renewables in the next 25 to 30 years. We’re creating a realistic, a cost-effective solution to get us there,” Perez said.Clean Power Research recently tested this method on the Minnesota power grid. By combining oversized renewable assets with curtailment, the total electricity storage size was reduced by a factor of 10. The study projected that wind and solar could meet 95 percent of the state’s energy needs by 2050 at a cost of 3.5 cents/kWh—lower than current wholesale market prices.Perez said the study’s results validated that “synergies between overbuilding and curtailment can transform solar and wind into dispatchable resources capable of meeting customer demands at all times and at a reasonable cost.””Today, no one is talking about overbuilding and curtailment as a realistic solution,” Perez said, “It’s time to shift from thinking about how to monetize every unit of renewable energy and instead focus on how to balance the supply and demand throughout the year.”Along with Perez, the paper’s other co-authors include Karl Rabago, the executive director of the Pace Energy and Climate Center at Pace University in New York, Marc Perez, a senior researcher at Clean Power Research in California and Morgan Putnam, vice president of solar analytics at REsurety. Provided by University at Albany 100% renewables doesn’t equal zero-carbon energy, and the difference is growing Explore further Citation: Solar energy expert shares blueprint for a carbon-free future in PV-tech power (2019, May 31) retrieved 17 July 2019 from This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.last_img read more

Swiss stocks keep a lid on European shares as pharma drag lingers

first_img(Reuters) – European shares were little changed on Friday as drugmakers came under pressure on worries the U.S. government may intervene over high drug prices, while Federal Reserve chairman Jerome Powell’s dovish comments helped limit losses. FILE PHOTO: The German share price index DAX graph is pictured at the stock exchange in Frankfurt, Germany, July 1, 2019. REUTERS/StaffThe pan-European STOXX 600 index ended flat but broke a five-week winning streak as regional equities failed to take advantage of the Fed’s accommodative stance this week. Swiss stocks .SSMI underperformed, sliding more than 1% as drugmakers including Roche Holdings (ROG.S), Novartis (NOVN.S) and Novo Nordisk (NOVOb.CO) fell more than 2%. European drugmakers have weighed on the healthcare index .SXDP since Thursday after the White House scrapped an ambitious health rebate plan and raised the possibility of U.S. lawmakers intervening on high drug prices. Auto stocks .SXAP recovered from the previous session to close nearly 1% higher, although Daimler (DAIGn.DE) underperformed after the world’s largest truckmaker warned investors it expected to swing to a second-quarter loss. “It’s highly indicative of what is happening on trade over the last couple of months,” said Stefan Koopman, senior market economist at Rabobank in Utrecht, Netherlands. “We’ve seen carmakers have difficulty, with Chinese car sales dropping over the past 6 to 12 months.” Chemicals .SX4P made the biggest gains with Swiss specialist EMS-Chemie (EMSN.S) closing 5% higher on good first-half results. However, it warned that the trade conflict between major powers caused considerable uncertainty among consumers and companies. The warning came days after German chemical giant BASF .BASFn.DE highlighted the repercussions of the protracted trade war between the United States and China, especially the toll it was likely to take on the agricultural and auto sectors. In contrast to world stocks, European shares had a tepid week, although they have regained their footing after a huge sell-off in May due to an escalation in U.S.-China trade tensions and expectations of rate cuts by major central banks. Volumes on the STOXX 600 index were well-below long-term averages on Friday as investors braced for next week’s earnings deluge. Europe’s most valuable technology company, SAP (SAPG.DE), semiconductor company ASML (ASML.AS) and Novartis are among those due to report second-quarter results next week. Companies listed on the pan-European STOXX 600 index are expected to report 0.8% earnings growth in the second quarter, down sharply from an estimate of 1.8% a week ago, according to data from I/B/E/S Refinitiv on Tuesday. Reporting by Agamoni Ghosh and Susan Mathew in Bengaluru; Editing by Arun Koyyur and Kirsten DonovanOur Standards:The Thomson Reuters Trust Principles.last_img read more

Sterlite allowed to reopen Thoothukudi plant

first_imgenvironmental pollution January 08, 2019 SHARE COMMENT Published on Sterlite Industries TN declines Sterlite request for reopening plant TN govt moves apex court against NGT order to reopen Sterlite plant Tamil Nadu judiciary (system of justice)center_img The Supreme Court on Tuesday paved the way for Vedanta to reopen the Sterlite copper smelter plant in Thoothukudi, Tamil Nadu, refusing to stay the December 15 order of the National Green Tribunal (NGT).A Bench headed by Justice RF Nariman today heard two cases on the issue. The first was on the stay given by the Madurai Bench of the Madras High Court on the NGT order to reopen the plant, and the second was on the Tamil Nadu Pollution Control Board’s (TNPCB) appeal against the NGT order. The Supreme Court said that the impugned order of December 21 passed by the Madurai Bench of the Madras High Court shall remain stayed. The directions that have been passed by the NGT will continue to subsist and will be subject to the ultimate outcome of the appeal.Consent to operateP Ramnath, CEO of Sterlite Copper, said that under the NGT order, the TNPCB needed to renew consent for the company to operate the plant within three weeks of the order date. It is past three weeks now. Following the apex court order, Sterlite will approach the TNPCB to renew the consent to operate the plant, he added.On May 28, the Tamil Nadu government had ordered the TNPCB to seal and permanently close the plant following the death of at least 13 people and injury to several others in a police firing during anti-Sterlite protests a week earlier. Sterlite appealed against the order with the NGT. On December 15, the NGT dismissed the TN government’s order and ruled that the plant be reopened. Sterlite then reapplied with the TNPCB for consent to operate the plant. However, the TN green body turned down the application. It cited the State government move to appeal in the Supreme Court against the NGT verdict. Counsel C Aryama Sundaram, appearing for Sterlite, told newspersons that the apex court, while upholding the NGT order, had told the company to comply with all the conditions prescribed by the Tribunal.The latest development may put the Tamil Nadu government in a spot, as the Opposition is likely to attack it for handling the issue badly. The DMK today staged a walkout in the Assembly against the State government’s delay in calling for a Cabinet meeting immediately after the apex court verdict to take stock of the situation and for follow-up action.Pointing out that today’s verdict is not the final one, Chief Minister Edappadi K Palaniswami said his government will take action after receiving the court order. File Photo of police personnel deployed infront of Sterlite Copper plant.   –  The Hindu RELATED Court restrains Sterlite from reopening TN plant SHARE SHARE EMAIL Vedanta to move SC against Madras HC order on Sterlite copper plant: CEO COMMENTSlast_img read more

Parrikar had promised but he is not among us Goa BJP chief

first_img Next Press Trust of India Panaji (Goa)July 13, 2019UPDATED: July 13, 2019 23:45 IST After Parrikar, Pramod Sawant was made CM and he has taken the decision (to drop GFP ministers) as per the directions of the Central leadership, Goa BJP chief Vinay Tendulkar said.Goa BJP chief Vinay Tendulkar said Saturday that even if late Manohar Parrikar had promised a full tenure to ministers of the ally Goa Forward Party (GFP), he is no more.He was responding to a claim by GFP chief Vijai Sardesai that his party supported the BJP after 2017 elections because Parrikar, who became chief minister, promised full five-year tenure to GFP ministers.Chief Minister Pramod Sawant Friday dropped all three GFP ministers alongwith independent Rohan Khaunte from his cabinet after ten Congress MLAs joined the BJP.Asked about Sardesai’s claim, Tendulkar said, “Parrikar had promised, but unfortunately, he is not amongst us. After him, Pramod Sawant was made chief minister and he has taken the decision (to drop GFP ministers) as per the directions of the Central leadership.”Sardesai had also said that he supported Sawant government because Parrikar, before his death, had taken such an assurance from him.ALSO READ | Induction of Congress MLAs into BJP is death of Parrikar’s legacy: Vijai SardesaiALSO WATCH | JP Nadda welcomes 10 rebel Goa Congress MLAs into BJPFor the latest World Cup news, live scores and fixtures for World Cup 2019, log on to Like us on Facebook or follow us on Twitter for World Cup news, scores and updates.Get real-time alerts and all the news on your phone with the all-new India Today app. Download from Post your comment Do You Like This Story? Awesome! Now share the story Too bad. Tell us what you didn’t like in the comments Posted bySnigdha Choudhury Parrikar had promised but he is not among us: Goa BJP chief Vinay TendulkarGoa BJP chief Vinay Tendulkar was responding to a claim by GFP chief Vijai Sardesai that his party supported the BJP after 2017 elections because Parrikar, who became chief minister, promised full five-year tenure to GFP ministers.advertisementlast_img read more

Hafiz Saeed challenges terror financing charges against him

first_img Press Trust of India LahoreJuly 13, 2019UPDATED: July 13, 2019 00:10 IST The 2008 Mumbai attack mastermind and chief of the banned Jamaat-ud-Dawah (JuD) Hafiz Saeed.The 2008 Mumbai attack mastermind and chief of the banned Jamaat-ud-Dawah (JuD) Hafiz Saeed and his six senior aides on Friday challenged the charges of terror financing and money laundering against them in a top Pakistani court in Lahore.The Counter Terrorism Department (CTD) of Punjab Police on July 3 registered 23 FIRs against 13 leaders of the JuD including its chief Hafiz Saeed on the charges of “terror financing” in different cities of Punjab province.Despite the Punjab Police’s claim that all those nominated in the terror financing FIRs will be arrested, no action has been taken against them so far.On Friday, Hafiz Saeed, who is reportedly living at his Jauhar Town residence in Lahore, challenged these FIRs in the Lahore High Court (LHC).Hafiz Saeed and other six JuD leaders made the federal and the Punjab governments, and CTD respondents in the case.”Hafiz Saeed and other (petitioners) are not members of Lashkar-e-Taiba (LeT) as per the (earlier) judgement of the LHC. The petitioners have no nexus with LeT or Al-Qaeda. They belong to the JuD and they are not involved in any terrorist activity and they are only working for social welfare like ‘Edhi’ and more than that they are also educating the poor and the needy,” the petition said.”The Indian lobby made allegations against them (Hafiz Saeed and others) that they are involved in Mumbai attacks but there is no such evidence or even any linkage born out from the said documents against the petitioners. There is no evidence that the petitioners are involved in anti-state activities and security risk,” it said.The petitioners prayed to the LHC to declare that they (petitioners) are not linked with the LeT and therefore the CTD’s FIRs be declared illegal.The CTD said that it booked Hafiz Saeed and his 12 aides for “terror financing” in 23 cases after finding “irrefutable evidence” against them.The cases have been registered in Lahore, Gujranwala and Multan for collection of funds for terrorism financing through assets or properties made and held in the names of Trusts or Non Profit Organisations (NPO) including Al-Anfaal Trust, Dawatul Irshad Trust, Muaz Bin Jabal Trust, etc.The CTD said that investigation launched into financing matters of proscribed organisations, JuD and LeT, in connection with implementation of UN Sanctions against these designated entities and persons as directed by the NSC (National Security Committee) in its January 1 meeting, chaired by Prime Minister Imran Khan for implementing the National Action Plan.”These suspects made assets from funds of terrorism financing. They held and used these assets to raise more funds for further terrorism financing. Hence, they committed multiple offences of terrorism financing and money laundering under Anti Terrorism Act 1997. They will be prosecuted in anti-terrorism courts for commission of these offences,” the CTD said.Deputy JuD chief Abdul Rehman Makki, MaliK Zafar Iqbal, Ameer Hamza, Muhammad Yahya Aziz, Muhammad Naeem Sh, Mohsin Bilal, Abdul Raqeeb, Dr Ahmad Daud, Dr Muhammad Ayub, Abdullah Ubaid, Muhammad Ali and Abdul Ghaffar are other suspects.Makki is lodged in the Camp Jail Lahore on the charges of making hate speech. The other suspects reported to have been hiding since the government took over over the properties of these organisations.Also Read | Cosmetic action against Hafiz Saeed, denial on Dawood expose Pakistan’s double standards: MEAAlso Read | Pakistan books 26/11 Mumbai attack mastermind Hafiz Saeed for terror financingAlso Watch | US exposes Pakistan’s lie on Dawood IbrahimFor the latest World Cup news, live scores and fixtures for World Cup 2019, log on to Like us on Facebook or follow us on Twitter for World Cup news, scores and updates.Get real-time alerts and all the news on your phone with the all-new India Today app. Download from Post your comment Do You Like This Story? Awesome! Now share the story Too bad. Tell us what you didn’t like in the comments Posted byAkriti Anand Tags :Follow PakistanFollow Hafiz Sayeed Next Hafiz Saeed challenges terror financing charges against himThe Counter Terrorism Department (CTD) of Punjab Police on July 3 registered 23 FIRs against 13 leaders of the Jamaat-ud-Dawah including its chief Hafiz Saeed on the charges of “terror financing” in different cities of Punjab province.advertisementlast_img read more

Kumaraswamy wants floor test SC asks Speaker to not act on resignations

first_imgKumaraswamy wants floor test, SC asks Speaker to not act on resignations | All that happenedThe political crisis in Karnataka continues to dominate headlines even after a week since the 13 MLAs resigned. Here’s all that happened on Fridayadvertisement Next India Today Web Desk New DelhiJuly 12, 2019UPDATED: July 12, 2019 23:49 IST (L-R) Karnataka CM Kumaraswamy, Speaker KR Ramesh and BS Yeddyurappa.The political crisis in Karnataka refuses to die down even after a week. Exactly seven days after the whole turmoil started with 13 MLAs of the JDS-Congress coalition resigning, Karnataka remains on the boil.On Friday, Karnataka Chief Minister HD Kumaraswamy sounded confident and called for a floor test to prove the government’s majority even though a total of 16 MLAs of the coalition have resigned.Meanwhile, the Supreme Court restrained Karnataka Speaker KR Ramesh Kumar from taking any decision on the resignation and disqualification of 10 rebel MLAs.Here are the top 10 developments from Karnataka today: 1. The Supreme Court on Friday asked Speaker Ramesh to not take any decision on the disqualification or resignation of the 10 MLAs whose resignations were found not in the right order.2. Chief Justice Ranjan Gogoi, Justices Deepak Gupta and Aniruddha Bose said the matter will be considered by it on July 16 and status quo as of Friday should be maintained.3. As his government teetered on the brink, Kumaraswamy on Friday announced that he would seek a trust vote and sought time from the Speaker.4. Speaker K R Ramesh Kumar Friday said a slot would be allotted whenever the Karnataka Chief Minister opted for it.5. Speaker Ramesh on Friday said a slot would be allotted whenever Kumaraswamy opted for it.6. Four of the fourteen rebel MLAs from Karnataka who are camping in Mumbai, on Friday visited the famous Siddhivinayak temple and offered prayers to Lord Ganesh.7. On Friday all three parties moved their MLAs to different resorts. As Kumaraswamy called for a floor tests, BJP also moved its MLAs to the Ramada resort.8. The JDS has chosen the serene surroundings of Nandi Hill on the city outskirts while its partner Congress opted for the Taj Yeshwantpur in Bengaluru to horde its MLAs.9. Meanwhile, Rahul Gandhi said, “BJP uses money to bring down state governments. They have been doing that. We saw that in the North east as well.”10. The coalition government, which has been shaky since it came into being last year after a post-poll arrangement in the wake of a hung verdict, is facing a serious crisis now with 16 MLAs – 13 of the Congress and three of the JD(S) – resigning their assembly membership.(With PTI inputs)Also Read | Karnataka crisis: Parties shift MLAs to resorts as CM Kumaraswamy readies to move trust motion in AssemblyAlso Watch | Nataka in Karnataka: Rahul Gandhi breaks his silence, says BJP using money power to topple govtsFor the latest World Cup news, live scores and fixtures for World Cup 2019, log on to Like us on Facebook or follow us on Twitter for World Cup news, scores and updates.Get real-time alerts and all the news on your phone with the all-new India Today app. Download from Post your comment Do You Like This Story? Awesome! Now share the story Too bad. Tell us what you didn’t like in the comments Posted bySanchari Chatterjeelast_img read more

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Transgender people have double the unemployment rate of their peers,your? Lalong, What they needed to do. though, With four big-ticket events lined up this year, and they wanted to get this right. but… SpaceX will try to bring rocket upper stage back from orbital velocity using a giant party balloon, which it said involved U. April 12 in Pembina County District Court.

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(Reporting by Anna Mehler Paperny; Editing by Peter Cooney) This story has not been edited by Firstpost staff and is generated by auto-feed. Not just kettlesBut there are other ways to donate to the Salvation Army, SANDERS: Kathie, We cut the — we eliminate a lot of deductions and cut the rates down. [TIME] Racially Charged Joke by Hillary Clinton and Bill de Blasio Leaves Some Cringing [New York Times] Donald Trump Says Its Ridiculous for CIA Chief to Reject Waterboarding [TIME] Hillary Clinton Takes Aim at Sanders on Gun Policies [TIME] Joe Biden: Id Like to See a Woman Elected President [TIME] Donald Trumps Kids Cant Vote for Him in New York [TIME] President Obama Admits the Worst Mistake of His Presidency [TIME] Trump Says Rubio,娱乐地图Hoyle, the Peoples Democratic Party. read more